You are FREE to Read and Download any Book. Click the button below and Create a FREE account. Don't waste your time, continue to see developments from around the world through BOOK.
|Author||: Vladimir P. Torchilin|
|Editor||: CRC Press|
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.
|Author||: Brittany Kaiser|
In this explosive memoir, a political consultant and technology whistleblower reveals the disturbing truth about the multi-billion-dollar data industry, revealing to the public how companies are getting richer using our personal information and exposing how Cambridge Analytica exploited weaknesses in privacy laws to help elect Donald Trump. When Brittany Kaiser joined Cambridge Analytica - the UK-based political consulting firm funded by conservative billionaire and Donald Trump patron Robert Mercer - she was an idealistic young professional working on her fourth degree in human rights law and international relations. A veteran of Barack Obama's 2008 campaign, Kaiser's goal was to utilize data for humanitarian purposes, most notably to prevent genocide and human rights abuses. But her experience inside Cambridge Analytica opened her eyes to the tremendous risks that this unregulated industry poses to privacy and democracy.Targeted is Kaiser's eyewitness chronicle of the dramatic and disturbing story of the rise and fall of Cambridge Analytica. She reveals to the public how Facebook's lax policies and lack of sufficient national laws allowed voters to be manipulated in both Britain and the United States, where personal data was weaponised to spread fake news and racist messaging during the Brexit vote and the 2016 election. But the damage isn't done Kaiser warns; the 2020 election can be compromised as well if we continue to do nothing. In the aftermath of the U.S. election, as she became aware of the horrifying reality of what Cambridge Analytica had done in support of Donald Trump, Kaiser made the difficult choice to expose the truth. Risking her career, relationships, and personal safety, she told authorities about the data industry's unethical business practices, eventually testifying before Parliament. Packed with never-before-publicly-told stories, Targeted goes inside the secretive meetings with Trump campaign personnel and details the promises Cambridge Analytica made to win. Throughout, Kaiser makes the case for regulation, arguing that legal oversight of the data industry is not only justifiable but essential to ensuring the long-term safety of our democracy.
|Author||: Ann L. Jackman,Christopher P. Leamon|
|Editor||: Springer Science & Business Media|
Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.
|Author||: Richard M. Schultz|
|Editor||: Springer Science & Business Media|
There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.
|Author||: Prashant Kesharwani,Umesh Gupta|
|Editor||: Academic Press|
Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors
|Author||: Mike Smith|
Nowadays, we fast-forward through commercials and we only pick up magazines at the doctor’s office (and even then only if our phone’s battery power is low!). But the one place of advertising we cannot avoid for longer than a few minutes is online--the vast and shifting Internet universe filled with pop-ups and our own personalized cookies. In fact, an advertising avenue that barely existed 20 years ago is now the second-largest advertising channel in the United States--and is still growing!Part history book, part guidebook, part prediction for the future, Targeted tells the story of the companies, individuals, and innovations driving this revolution. This one-of-a-kind resource takes readers behind the scenes--examining the growth of digital advertising, its enormous potential, and the technologies that are changing the game forever. Author and COO Mike Smith, a proven authority on how using real-time bidding systems with finesse can dramatically promote online advertising and branding, has provided an essential resource for anyone interested in finding and connecting with customers in the astronomically large universe we call the Internet that is only growing more aware and specialized for each of its millions of users.
|Author||: Christina Diaz Gonzalez|
|Editor||: Scholastic Inc.|
Cassie Arroyo, an American studying in Rome, has her world ripped apart when someone tries to kill her father, an art history professor at an Italian university. Is she their next target? Cassie sets out to uncover what is happening, only to learn that she is a member of an ancient bloodline that enables her to use the Spear of Destiny--a legendary object that can alter the future. Now running from a secret organization intent on killing those from her bloodline, Cassie must--with the help of some friends--decipher the clues that will lead her to the Spear. Christina Diaz Gonzalez has created a fast-paced thrill-ride of a book, rich with riddles and myth, that young readers will not want to put down.
|Author||: Zuhair Kashmeri,Brian McAndrew|
|Editor||: James Lorimer & Company|
A provocative look at one of Canada's biggest tragedies On March 16, 2005, almost twenty years after one of the biggest mass murders in Canadian Aviation history, the Air-India Case concluded with a verdict that authors Zuhair Kashmeri and Brian McAndrew predicted sixteen years ago when Soft Target was first published: not guilty. In this second edition, the two offer a detailed foreword that brings readers up-to-date with some startling new information surrounding the twin bombings on June 23, 1985 in the air over the Atlantic, and on the ground in Japan, which left 331 people dead. They offer key details from the trial of Ripudaman Singh Malik and Ajaib Singh Bagri that took place in a specially-built Vancouver courtroom, leads that were not followed up, and more details of India's intelligence service's clandestine interference in Canada. They explain how their own prediction that justice would not be found because of a botched investigation came true, and that only a public inquiry will offer closure to the families of the victims.
|Author||: Almut Mecke|
The synthesis of tamoxifen and 4 hydroxytamoxifen analogs for estrogen receptor targeted applications
|Author||: Matthew Riley Lashley|
|Author||: Jens Koed Madsen|
|Editor||: Springer Nature|
This book examines the psychology behind micro-targeted tactics used in election campaigning and the advent of increasingly sophisticated dynamic Agent-Based Models (ABMs). It discusses individual profiling, how data and modelling are deployed to enhance the effectiveness of persuasion and mobilization efforts in campaigns, and the potential limitations of these approaches. Madsen particularly explores how psychological insight and personal data are used to generate individualised models of voters and how these in turn are applied to optimise persuasion strategies tailored to a specific person. Finally, the book considers the broader democratic dilemmas raised by the introduction of these tactics into politics and the critical civic importance of understanding how these campaigns function.This timely work offers fresh insights for students and scholars of political psychology, philosophy, political marketing, media, and communications.
|Author||: Mark Greaney|
From #1 New York Times bestselling author Mark Greaney comes the second entry in the explosive thriller series featuring the lethal assassin known as the Gray Man. When an old comrade Court Gentry thought was dead returns to haunt him, his own life is put in the crosshairs. The man wants Court to complete a mission, with one crucial catch to his orders: Instead of a difficult assassination, the job will entail a nearly impossible kidnapping--and Court must return his quarry to the very CIA team that turned on him.
|Author||: Natalia L. Komarova,Dominik Wodarz|
|Editor||: Springer Science & Business Media|
Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.
|Author||: Katie Reus|
Hidden in plain sight… Former Marine sniper and current NSA agent Jack Stone has a new face to go with his new identity. But he still has the same tortured memories—which include the woman he let get away years ago, when they were teenagers. Now his new assignment in Miami will put him so close to the woman he’s never been able to forget, he could reach out and touch her—if only she weren’t under suspicion. When Sophie Moreno uncovers evidence linking the medical supply company she works for with arms smuggling—and worse—she doesn’t know who to turn to. After a shocking betrayal, she realizes the only person she can trust is a mysterious new person in the company—a man with hauntingly familiar eyes. As Sophie questions her intense attraction to this man and Jack struggles not to blow his cover, the two of them must race against the clock to stop terrorists from killing scores of people—starting with them. FIRST IN A NEW SERIES!
|Author||: Iris Johansen|
Assisting the president's catatonic daughter to recover from the trauma of witnessing a murder, Melissa Riley and her sister place their safety in the hands of mysterious underworld agent Michael Travis. Reprint.
|Author||: Randi Jenssen Hagerman,Robert L. Hendren|
|Editor||: Oxford University Press (UK)|
This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have led to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment.
|Author||: David Baldacci|
|Editor||: Grand Central Publishing|
The President knows it's a perilous, high-risk assignment. If he gives the order, he has the opportunity to take down a global menace, once and for all. If the mission fails, he would face certain impeachment, and the threats against the nation would multiply. So the president turns to the one team that can pull off the impossible: Will Robie and his partner, Jessica Reel. Together, Robie and Reel's talents as assassins are unmatched. But there are some in power who don't trust the pair. They doubt their willingness to follow orders. And they will do anything to see that the two assassins succeed, but that they do not survive. As they prepare for their mission, Reel faces a personal crisis that could well lead old enemies right to her doorstep, resurrecting the ghosts of her earlier life and bringing stark danger to all those close to her. And all the while, Robie and Reel are stalked by a new adversary: an unknown and unlikely assassin, a woman who has trained her entire life to kill, and who has her own list of targets--a list that includes Will Robie and Jessica Reel.
|Author||: Christina Diaz Gonzalez|
|Editor||: Scholastic Inc.|
WHO WILL CONTROL DESTINY? Cassie Arroyo has the ability to use the Spear of Destiny. And despite knowing the dangers of such a powerful object, she uses it to shape the future and save her father's life. The consequences of that small choice are larger than Cassie could ever have imagined. It produced a chain reaction - and now, in her visions of the future, Cassie sees chaos and death spreading across Rome. With the help of her friend Asher, Cassie is determined to fix the future she's created . . . but it's not going to be simple. The spear's been stolen by people who want to use it for their own dark purposes. Can Cassie recapture the spear before it's used against her? And will she be able to undo the harm she's caused, or will she only cast the world into greater chaos? Christina Diaz Gonzalez's Return Fire is a nonstop, action-packed adventure, full of mystery and intrigue, that will take you on a wild and wonderful ride across Italy.