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Patient H M by Luke Dittrich
“Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. Praise for Patient H.M. “An exciting, artful blend of family and medical history.”—The New York Times “In prose both elegant and intimate, and often thrilling, Patient H.M. is an important book about the wages not of sin but of science.”—The Washington Post “Spellbinding . . . The fact that Dittrich looks critically at the actual process of scientific investigation is just one of the things to admire about Patient H.M.”—The New York Times Book Review “Patient H.M. tells one of the most fascinating and disturbing stories in the annals of medicine, weaving in ethics, philosophy, a personal saga, the history of neurosurgery, the mysteries of human memory, and an exploration of human ego.”—Sheri Fink, M.D., Pulitzer Prize winner and author of Five Days at Memorial “This is classic reporting and myth-making at the same time.”—Colum McCann, author of Let the Great World Spin *Kirkus Reviews (starred review)
Left Ventricular Assist Devices An Issue Of Cardiology Clinics E Book by John A. Elefteriades
A left ventricular assist device (LVAD) is a surgically implanted pump that helps the left ventricle pump blood to the rest of the body. The purpose of this issue is to let cardiologists know about the latest devices, their complications, and the clinical situations in which they are most beneficial.
Heart Failure An Issue Of Cardiology Clinics by Howard J Eisen
Over 5.7 million people in America carry a diagnosis of heart failure, the incidence of which approaches 1 in 100 people over the age of 65. The cost to society is estimated at $29 billion annually and over 1.1 million hospital admissions. For hospitalized heart failure patients, the 30-day readmission rate approaches 25%. As our population ages these numbers are expected to grow. This issue of Cardiology Clinics helps practitioners to manage patients at all ACC/AHA stages of heart failure and addresses key issues that include sudden cardiac death, arrhythmias, acute decompensated heart failure, and heart failure with preserved ejection fraction.
Permanent Present Tense by Suzanne Corkin
In 1953, 27-year-old Henry Gustave Molaison underwent an experimental “psychosurgical” procedure—a targeted lobotomy—in an effort to alleviate his debilitating epilepsy. The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain. Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.
Mechanical Circulatory Support A Companion To Braunwald S Heart Disease Ebook by Robert L. Kormos
Mechanical Circulatory Support, by Drs. Robert L. Kormos and Leslie W. Miller, provides the clinically relevant information you need to effectively use this therapy to treat and manage end-stage cardiovascular disease. In this Companion to Braunwald’s Heart Disease, the world’s most prominent experts in mechanical circulatory support (MCS) cover basic science, device construction, clinical applications, socioeconomic implications, future directions, and more. Stay on top of hot topics - including innovative devices like continuous flow pumps, next-generation centrifugal pumps, and total artificial hearts; MCS for pediatric and congenital heart disease; cellular, molecular, genomic, and functional changes that occur in the failing heart in response to MCS; and Interagency Registry of Mechanically Assisted Circulatory Support (INTERMACS) as a tool to track and advance clinical practice. Tap into discussions of hot topics in mechanical circulatory support (MCS), including current types of devices and clinical settings for MCS; MCS for pediatric and congenital heart disease; myocardial recovery, regenerative therapy, bleeding and thrombosis with MCS; cellular, molecular, genomic, and functional changes that occur in the failing heart in response to MCS; and Interagency Registry of Mechanically Assisted Circulatory Support (INTERMACS) as a tool to track and advance clinical practice. Get a complete picture of the role of mechanical circulatory support in treatment through coverage of device construction, clinical applications, socioeconomic implications, and future directions. Master the pathophysiology and rationale of treatment with discussions of basic science in addition to clinically-relevant information and current clinical practice guidelines. Apply the expertise of the world’s most prominent leaders in mechanical circulatory support.
Patient Based Approaches To Cognitive Neuroscience by Todd E. Feinberg
The cognitive disorders that follow brain damage are an important source of insight into the neural bases of human thought. Although cognitive neuroscience is sometimes equated with cognitive neuroimaging, the patient-based approach to cognitive neuroscience is responsible for most of what we now know about the brain systems underlying perception, attention, memory, language, and higher-order forms of thought including consciousness. This volume brings together state-of-the-art reviews of the patient-based approach to these and other central issues in cognitive neuroscience, written by leading authorities. Part I covers the history, principles, and methods of patient-based neuroscience: lesion method, imaging, computational modeling, and anatomy. Part II covers perception and vision: sensory agnosias, disorders of body perception, attention and neglect, disorders of perception and awareness, and misidentification syndromes. Part III covers language: aphasia, language disorders in children, specific language impairments, developmental dyslexia, acquired reading disorders, and agraphia. Part IV covers memory: amnesia and semantic memory impairments. Part V covers higher cognitive functions: frontal lobes, callosal disconnection (split brain), skilled movement disorders, acalculia, dementia, delirium, and degenerative conditions including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Contributors: Michael P. Alexander, Russell M. Bauer, Kathleen Baynes, D. Frank Benson, H. Branch Coslett, Jeffrey L. Cummings, Tim Curran, Antonio R. Damasio, Hanna Damasio, Ennio De Renzi, Maureen Dennis, Mark D'Esposito, Martha J. Farah, Todd E. Feinberg, Michael S. Gazzaniga, Georg Goldenberg, Jordan Grafman, Kenneth M. Heilman, Diane M. Jacobs, Daniel I. Kaufer, Daniel Y. Kimberg, Maureen W. Lovett, Richard Mayeux, M.-Marsel Mesulam, Bruce L. Miller, Robert D. Nebes, Robert D. Rafal, Marcus E. Raichle, Timothy Rickard, David M. Roane, David J. Roeltgen, Leslie J. Gonzalez Rothi, Eleanor M. Saffran, Daniel L. Schacter, Karin Stromswold, Edward Valenstein, Robert T. Watson, Tricia Zawacki, Stuart Zola.
I. Learning & Memory: Elizabeth Phelps & Lila Davachi (Volume Editors) Topics covered include working memory; fear learning; education and memory; memory and future imagining; sleep and memory; emotion and memory; motivation and memory; inhibition in memory; attention and memory; aging and memory; autobiographical memory; eyewitness memory; and category learning.
Heart Failure: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Heart Failure. The editors have built Heart Failure: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Heart Failure in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Failure: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Forgetting by D. Draaisma
Does forgetting signal a failing mind? What can be done to ward off forgetfulness? Is there an upside to forgetting? In his highly praised book The Nostalgia Factory, renowned memory scholar Douwe Draaisma explored the puzzling logic of memory in later life with humor and deep insight. In this compelling new book he turns to the "miracle" of forgetting. Far from being a defect that may indicate Alzheimer's or another form of dementia, Draaisma claims, forgetting is one of memory's crucial capacities. In fact, forgetting is essential. Weaving together an engaging array of literary, historical, and scientific sources, the author considers forgetting from every angle. He pierces false clichés and asks important questions: Is a forgotten memory lost forever? What makes a colleague remember an idea but forget that it was yours? Draaisma explores "first memories" of young children, how experiences are translated into memory, the controversies over repression and "recovered" memories, and weird examples of memory dysfunction. He movingly examines the impact on personal memories when a hidden truth comes to light. In a persuasive conclusion the author advocates the undervalued practice of "the art of forgetting"--a set of techniques that assist in erasing memories, thereby preserving valuable relationships and encouraging personal contentment.