Blood And Loss
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|Author||: Michael F. Murphy,Derwood H. Pamphilon|
|Editor||: John Wiley & Sons|
This new edition of the comprehensive guide to transfusion medicine is now fully revised and updated. The Third Edition includes two new sections, one on alternatives to blood transfusion, and one on cellular and tissues therapy and organ transplantation. It focuses on clinical aspects but also covers background science and organizational issues. This timely volume highlights controversial issues and provides advice for everyday clinical questions in transfusion medicine. Practical Transfusion Medicine, Third Edition, is an essential manual for all those working in modern transfusion medicine.
|Author||: Kerena Swan|
Sarah With one eye on the rear view mirror and the other on the road ahead, Sarah is desperate to get as far away from the remote Scottish cabin as she can without attracting attention. But being inconspicuous isn't easy with a black eye and clothes soaked in blood... ... and now the fuel tank is empty. DI Paton When a body is discovered in a remote cabin in Scotland, DI Paton feels a pang of guilt as he wonders if this is the career break he has been waiting for. But the victim is unidentifiable and the killer has left few clues. Jenna With the death of her father and her mother's failing health, Jenna accepts her future plans must change but nothing can prepare her for the trauma yet to come. Fleeing south to rebuild her life Sarah uncovers long-hidden family secrets. Determined to get back what she believes is rightfully hers, Sarah thinks her future looks brighter. But Paton is still pursuing her... ... and he's getting closer.
|Author||: Alex Barclay|
|Editor||: Delacorte Press|
In this electrifying thriller—a bestseller in Great Britain and Ireland—Alex Barclay creates a stunning array of contrasts—from the violence of a cop’s world to the fragility of an embattled marriage, from the danger of New York’s gritty streets to the quiet of a seaside Irish village. With brilliance and subtlety, Barclay delivers a nerve-wracking tale of a troubled family, facing a brutal danger rushing relentlessly out of the past. One year has passed since a kidnapping drama exploded into violence on a New York street. And for NYPD detective Joe Lucchesi, the memory of that terrible moment is still alive. Joe’s wife, Anna, has brought him and their teenage son to Ireland, hoping to repair their fragile marriage—and cut the cord between Joe and the job. But when the girlfriend of their son vanishes, Joe begins to suspect that the crime may have its roots in his old life—and that someone has followed him all the way there…. An outsider in Ireland, Joe watches with rising apprehension as local cops try to solve the disappearance—and then reacts with fury when his son becomes the leading suspect. Frantically, Joe tries to piece together clues to the crime, certain that a predator has come to Ireland in a twisted act of vengeance. And in a culture he doesn’t understand, among people who may or may not be his friends, Joe must find a way to strike back…against a vicious killer who has Joe’s family in his sights.... A novel that plunges like a knife, Darkhouse delves into the intimate struggles between a husband and wife, between lovers and desperate friends. Seething with menace and mounting dread, Alex Barclay’s ingenious tale of a family under siege ratchets up the suspense one shocking revelation at a time as it races to its shattering climax....
|Author||: Niels H Secher,J A Pawelczyk|
|Editor||: CRC Press|
A key factor in the treatment of the traumatized patients is the amount of blood lost since injury. This is relevant not simply from the point of view of transfusing blood but also in the body's response to the shock of blood loss. This book provides a framework for the understanding of the complex clinical effects of blood loss and outlines strategies for treatment in the trauma unit or intensive therapy unit. The international editorship and clinical research approach make this a unique, comprehensive and authoritative text which will be of use to everybody working in this field.
Effect of Total Volume Replenishment of Massive Obstetric Blood Loss on the Frequency and Severity of Multiple Organ Dysfunction Syndrome
|Author||: Vladyslav Sedinkin|
Effect of total volume replenishment of massive obstetric blood loss on the frequency and severity of multiple organ dysfunction syndromeVladyslav Sedinkin, Olena KlygunenkoState Establishment u2018Dnipropetrovsk Medical Academy of Health Ministry of Ukraineu2019. Department of Anaesthesiology, Intensive Care and Emergency Medicine of Postgraduate Faculty. Dnipropetrovsk, Ukraine.Background and Goal of Study: The Aim to evaluate the effect of total replenishment of massive obstetric blood loss in the frequency and severity of clinical manifestations of MODS.Materials and Methods: Having agreed with the local Ethics Committee and obtained the informed consents, 68 women (whose delivery or early postpartum period was complicated by acute severe hemorrhage with blood volume (BV) deficit of 44-52%) were examined. Patients were randomized into 2 groups depending on the characteristics of the BV replenishment. Both groups were similar in relation to age, height, gestation term, blood loss volume (2621u00b1613 ml). In 1 group (n=30) BV replenishment performed according to Ukrainian national protocol (relation between erythrocytes, FFP, and platelet (if necessary) is 1:1:1). In 2 group (n=38) 1500 IU of Prothrombin Complex Concentrate (PCC) (Octaplex) was added to therapy. Were assessed: the number of red blood cells, hemoglobin, hematocrit, standard coagulation, SaO2, liver-kidney complex. Clinical signs of MODS are accounted for myocardial insufficiency (frequency and duration of vasopressor support); respiratory dysfunction (frequency and duration of mechanical ventilation); acute kidney injury (frequency and duration of renal replacement therapy), gastrointestinal dysfunction (frequency and duration of the enteroparesis). The time points: 1, 3, 5, 7, 10, 14 and 28 days after delivery.Results and Discussion: Analysis showed that use of PCC reduced total infusion-transfusion volume by 24.5% (1300 ml). Comparative analysis of the frequency and severity of clinical manifestations of MODS is presented in Table 1. Patients 2 group had decreased frequency and duration of vasopressor support, frequency and duration of mechanical ventilation, had reduced the number of patients requiring renal replacement therapy, and it duration. The frequency gastrointestinal dysfunction reduced more than twice. This provided a significant reduction in the duration of stay in the ICU from 14.1u00b11.7 (1 group) to 7.8u00b12.1 days (2 group).Conclusion(s): Reducing the total volume of infusion-transfusion therapy provides a significant decrease in frequency of clinical signs of MODS and reduces the duration of stay in the ICU.
|Author||: Henry Kenneth Walker,Wilbur Dallas Hall,John Willis Hurst|
A guide to the techniques and analysis of clinical data. Each of the seventeen sections begins with a drawing and biographical sketch of a seminal contributor to the discipline. After an introduction and historical survey of clinical methods, the next fifteen sections are organized by body system. Each contains clinical data items from the history, physical examination, and laboratory investigations that are generally included in a comprehensive patient evaluation. Annotation copyrighted by Book News, Inc., Portland, OR
|Author||: Marilyn J. Cipolla|
|Editor||: Biota Publishing|
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
|Author||: Ulrich Franz Gruber|
|Editor||: Springer Science & Business Media|
The manifold problems of shock are still of great importance, diagnostic and therapeutic experience of the "severely ill" being supplied with new information almost every month. In the 5 periodicals which have found their way to my desk during the past few days there are no less than 10 interesting articles on questions concerning shock research [see Bibliography 41 b, 53 a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. The most urgent point still is to maintain as complete as possible the objective catalog of the various shock manifestations found in man and in animals - yet at the same time to view interpretations of these phenomena in their relative and temporal "truth". Problems of shock research are not only interesting for their scientific value but also for their clinical implication. In particular, almost every practicing physician is facing problems of blood replacement very frequent ly. The effective or circulating blood volume remains an important theoret ical and therapeutic problem in the shock field. For years, U. F. GRUBER has pursued this question clinically and experimentally. This volume deals with the world literature in an exceptionally thorough manner. This book is made more than a compilation by including a long list of original work done with F. D. MOORE in Boston, in the Surgical Department in Chur, with L. E. GELIN and S. E.
|Author||: Andrew B. Leibowitz,Suzan Uysal|
|Editor||: Cambridge University Press|
Close monitoring of patients during anesthesia is crucial for ensuring positive treatment outcomes and patient safety. The increasing availability of new technologies and the repurposing of older monitors means more patient data is at anesthesiologists' fingertips than ever before. However, this flood of options can be overwhelming. A practical resource for understanding this array of clinical monitoring options in anesthesia, this important text focuses on real-world applications in anesthesia and perioperative care. Reviewing the evidence for improved patient outcomes for monitoring technology, neurological monitoring, echocardiography systems and ultrasound are amongst the techniques covered in a head-to-toe approach. Statistics used by manufacturers to gain approval for their technology are discussed, as well as the under-appreciated risks associated with monitoring such as digital distraction. Future monitoring technologies including wearable systems are explored in depth. Focusing on applied practice, this book is an essential text for front-line healthcare professionals in anesthesia.
|Author||: Hans Gombotz,Kai Zacharowski,Donat Rudolf Spahn|
Patient Blood Management (PBM) is an innovative clinical concept that aims to reduce the need for allogenic blood transfusions, cut health-care costs, and avert or correct the risk factors related to blood transfusion, thus minimizing the rate of side effects and complications. This comprehensive hands-on volume offers a three-point approach for the implementation of PBM to improve patient outcome, focusing on how to prevent or treat anemia, reduce blood loss, and increase anemia tolerance. The book also goes beyond preoperative PBM, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. Special Features: Presents a clear three-pillar strategy for the application of PBM: diagnosis and treatment of anemia, reduction of peri-interventional blood loss, and optimization of the tolerance to anemia in the everyday clinical setting Covers issues such as PBM during surgery, requirements for modern transfusion medicine, ordering blood products, the role of pre-anesthesia clinics, benchmarking processes, and potential implications of PBM in the public health sector Overview of research in PBM including landmark studies and current clinical trials Boxes in each chapter highlighting key information, core statements, and summaries A multidisciplinary and international team of contributors experienced in PBM Patient Blood Management is a guide for clinicians and residents whose patients are at risk for anemia, coagulation disorders, or severe blood loss. Anesthesiologists, surgeons, and specialists involved in the use of blood and blood products can use the book for quick reference or to learn more about a leading-edge concept for optimizing patient safety and improving outcome.
|Author||: Petra Seeber,Aryeh Shander|
|Editor||: John Wiley & Sons|
To reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood. Meeting the need for a book covering the concepts of blood management as a trend towards multidisciplinary blood management, this new edition is an important resource, providing healthcare professionals with a tool to develop background knowledge in blood management, its organization, methods and tools. Practicing clinicians will be fully prepared to successfully start and run blood management programs.
|Author||: Institute of Medicine,Board on Health Sciences Policy,Committee on Sleep Medicine and Research|
|Editor||: National Academies Press|
Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
|Author||: Lisa Solis DeLong|
|Editor||: Tate Publishing|
Justin DeLong was a bright, energetic child when he was diagnosed with leukemia at age five. After going into remission for ten years, where he laughed and ran long-distance races and slowly entered adolescence, in July 2000 he succumbed to the disease twelve days after his fifteenth birthday. Lisa DeLong and her family were left to pick up the pieces. Then, six years later, they discovered their youngest son, Jacob, had leukemia too. This is Lisa's story of what it was like to have two sons with leukemia, a lifetime apart. As she struggles to understand how a loving God could allow this to happen, she searches for a way to keep her marriage, her family, and her own sanity together. Whether you're a mother, someone who has experienced cancer either in yourself or someone you love, or a medical professional, the story of these two Blood Brothers will allow you to see how, with faith, great triumph can come from unimaginable tragedy.--From publisher description.
|Author||: Robert Provenzano,Edgar V. Lerma,Lynda Szczech|
This concise and practical resource brings together recent advances in identifying and managing anemia of chronic disease (inflammation), genetically related anemia and anemia related to chronic end organ damage. Chapters provide a detailed analysis of the current science of anemia, approaches to different patient populations, comorbid conditions and nutritional aspects of anemia. Novel therapies focused on physiological pathways are introduced and discussed. Controversies from the perspective of subspecialists focused in treating major causes of anemia within their specific disciplines are also presented. Easy-to-reference and authored by experts in each clinical scenario, Management of Anemia is the launching point for learning more about this challenging and common condition.
|Author||: Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent|
|Editor||: World Bank Publications|
Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.
|Author||: Hunter B. Moore,Matthew D. Neal,Ernest E. Moore|
|Editor||: Springer Nature|
The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
|Author||: Jesmine Khan|
|Editor||: BoD – Books on Demand|
This book deals with a very common condition, anemia, which might interest not only the physicians but also other healthcare professionals and researchers dealing with anemic patients. The objective of this book was to collect and compile up-to-date information from reputable researchers of different countries of the world to disseminate the latest information about the common types of anemia in some specific physiological and pathological conditions including pathophysiology and the use of algorithms as a tool to minimize the laboratory tests and accurate diagnosis of the underlying cause. In total, there are 13 chapters in this book where the authors shared their research findings and real-life experiences in managing their patients with anemia.